Bioethics today has become a subject of wide public concern. Almost every one of its tenets is being seriously questioned and likely to be reformulated. Moreover, the pressure on bioethics continues to mount as the number of moral conflicts that buffet our society increases. What, then, will bioethics look like a decade from now? In the variety of approaches that have been employed in the practice of bioethics, one has dominated in the United States in the last decade and a (...) half. That approach is "principlism", the use of moral principles to address theoretical issues and to resolve conflicts at the bedside. Recently, however, bioethicists and others increasingly have realized the limitations of principlism and are calling for the development of alternative approaches such as phenomenology, hermeneutics, narrative ethics, casuistry, and virtue ethics. This book maps the debate over principlism and the future direction of U.S. bioethics. Part One consists of a sociological description of U.S. bioethics at the beginning of the 1990s, along with a defense of principlism by one of its major proponents. Part Two maps cross-cultural critiques of principlism, while Part Three covers five alternatives to it. Three essays in Part Four - by a bioethicist, a physician, and a theologian - reflect on the future of U.S. bioethics, principlism, and its alternatives. The Afterword emphasizes the place of religion and theological discourse in the alternative approaches and in the future of bioethics. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

The spatial dynamics of the optical emission from an array of 50 times 50 individual microcavity plasma devices is investigated. The array is operated in argon and argon-neon mixtures close to atmospheric pressure with an ac voltage. The optical emission is analysed with phase and space resolution. It has been found that the emission is not continuous over the entire ac period, but occurs once per half period. Each of the observed emission phases shows a self-pulsing of the discharge, with (...) several bursts of emission of fixed width and repetition rate. The number of emission bursts depends on applied voltage and frequency. Spatially resolved measurements prove that the emission bursts are formed by overlapping emission pulses from single discharge cavities. Intensity differences between positive and negative half-wave can be interpreted through spatially resolved measurements of single discharge cavities. (shrink)

When Dr. van Fleteren writes of the articles I criticized as dating from some twenty years ago, the unwary reader might infer that my criticism of those articles was, for its part, relatively recent. The fact is, however, that when the two connected articles I eventually criticized appeared in the volumes of Augustinian Studies, I wrote this reply while Fr. Robert Russell, of happy memory, was still at the helm, and was promised publication in the near future. Meanwhile, however, Fr. (...) Russell had the discourtesy to move on to a more intimate acquaintance with Augustine than any of us on this confused planet can boast of, and someone sowed cockle into field he had tended: in unaccountable fashion my article seems to have disappeared. Only a recent letter of inquiry on my part, and Fr. Allan Fitzgerald’s understanding reply, resulted in this renewal of dialogue between Dr. van Fleteren and me. Let me assure both Dr. van Fleteren and Fr. Fitzgerald that I am grateful for giving it exactly that form, a courteous dialogue. (shrink)

The phase space formulation of quantum mechanics is based on the use of quasidistribution functions. This technique was pioneered by Wigner, whose distribution function is perhaps the most commonly used of the large variety that we find discussed in the literature. Here we address the question of how one can obtain distribution functions and hence do quantum mechanics without the use of wave functions.

Abstract:This paper contends that rationality is more properly evaluated as a property of an organization’s relationships with its stakeholders than of the organization itself. We predicate our approach on the observation that stakeholders can hold goals quite distinct from those of owners and top managers, and these too can be rationally pursued. We build upon stakeholder theory and Weber’s classic distinction betweenwertrationalitatandzweckrationalitat, adding to them the “new institutionalist” concept of the organization field (1983, 1991). Stakeholders employ a variety of direct (...) and indirect mechanisms to rationalize relations with the firm. We discuss four: internal subunits, legislated stakeholder participation, legislated access to information, and direct stakeholder activism. These developments are blurring the distinction between the environment and the organization by importing the values and goals of external stakeholders into the internal organization. They are also precipitating a more structured set of relationships among the actors who comprise the field. To the extent that thezweckrationalitatvalues of managers and owners as well as thewertrationalitatconcerns of stakeholders are met, the firm is more rational. (shrink)

This book rounds off the study of St. Augustine's view of the human condition which Fr. O'Connell began in St. Augustine's Early Theory of Man, A.D. 386-391, and continued in St. Augustine's Confessions: The Odyssey of Soul. The central thesis of that first book, and the guiding hypothesis of the second, proposed that Augustine thought of us in "Plotinian" terms, as "fallen souls," and that he interpreted, in all sincerity, the teachings of Scripture as reflecting that same view. (...) class='Hi'>O'Connell sees the weightiest objection to his proposal as stemming from what scholars generally agree is Augustine's firm rejection of that view in his later works. The central contention here is that Augustine did indeed reject his earlier theory, but only for a short while. He came to see the text from Romans 9, 11 as apparently compelling that rejection. But then his firm belief that all humans are guilty of original sin would have left him traducianism as his only acceptable way of understanding the origin of sinful human souls. The materialistic cast of traducianism, however, always repelled Augustine. Hence, he struggles to elaborate a fresh interpretation of Romans 9,11, and eventually he finds one that permits him to return to a slightly revised version of his earlier view. That theory, O'Connell argues, is encased in both the De Civitate Dei and the final version of the De Trinitate. This terse summary barely hints at the richness of detail contained here: O'Connell beginswith a minute analysis of the third book of the De Libero Arbitrio, then of the letters and works ostensibly supporting rival chronological patterns which he must overturn in order to make his case. Finally, in the light of his findings, he offers fresh interpretations of Augustine's three mature masterpieces, On Genesis, The Trinity, and City of god. These, along with Fr. O'Connell's contention that Augustine's anti-Pelagian De Peccatorum Meritis et Remissione must have seen publication no earlier than A.D. 416/17, will doubtless fuel scholarly debate for some time to come. Indeed, Pelagianism made the question of the soul's origin so pivotal for Augustine, that few of our current interpretations of Augustine are likely to remain unaffected by the results of O'Connell's searching and provocative study. (shrink)

“... it ain't likely to have a radius of exactly zero,” is the conclusion of H. G. Dehmelt(1) from his Nobel Prize (1989) winning observations on trapped electrons. There are small discrepancies between Dehmelt's observations and the theoretical predictions of quantum electrodynamics (QED), which assumes that the electron is a point particle. Here we present evidence in support of Dehmelt's contention that the electron has a structure. Essentially, we point out that the nonrelativistic limit of QED is at variance with (...) a fundamental principle underlying all of physics, viz. the second law of thermodynamics. (shrink)

We discuss the profound influence which the Wigner distribution function has had in many areas of physics during its fifty years of existence.

William James’ celebrated lecture on “The Will to Believe” has kindled spirited controversy since the day it was delivered. In this lively reappraisal of that controversy, Father O’Connell contributes some fresh contentions: that James’ argument should be viewed against his indebtedness to Pascal and Renouvier; that it works primarily to validate our “over-beliefs” ; and most surprising perhaps, that James envisages our “passional nature” as intervening, not after, but before and throughout, our intellectual weighing of the evidence for belief.

What was the background to Newman’s rectorship of the Catholic University in Dublin? In 1845 the British government proposed to establish three non-denominational colleges in Ireland; some of the Irish bishops felt that it would be possible to work out a modus vivendi with the government. A slight majority of the bishops, however, opposed these so-called “godless” colleges and voted at the Synod of Thurles in 1850, to found a Catholic University in Ireland—a country that had been repeatedly decimated by (...) poverty and oppression, and a few years earlier the potato famine (1845-48). (shrink)

A narrative history of Oxford Movement, whereby a group of Anglican intellectuals, notably Newman, Pusey, Keble and Froude, attempted to restore to the Victorian Church of England the character of primitive Christianity. Many of the inherent principles, such as Apostolic Succession, were seen to be exemplified by the Catholic Church.

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 125 oped the theory of the swerve and applied it to the problem of voluntary action, also made use of it in his defense of moral responsibility" (l ~9-3o). The distinction Englert has in mind is between to hekousion and to eph' heroin, a distinction he had emphasized in his long chapter 5 on Aristotle, and insisted was important to Epicurus as well. But the promise is (...) not realized; we are told only that to eph' heroin is saved just as is to hekousion, by insisting that the swerve marks a causal break (135). The book then ends with some undigested matters: David Sedley's work on Epicurus 's On Nature and Don Fowler's suggestion that the mind's act of focus (epibole)might constitute a swerve. There is more to be said for their views. And more against. The last word on the subject has yet to be written. JEFFREY S. PURINTON Princeton University Gerard O'Daly. Augustine's Phzlosophy of Mind. Berkeley and Los Angeles: University of California Press, 1987. Pp. xii + 241. $35.00. Paul Rigby. Original Sin in Augustine's "Confessions." Ottawa: University of Ottawa Press, 1987. Pp. 137. Paper, $17.95. Augustine's philosophy of the human person is one of the most neuralgic points in his thought, and the neuralgic soreness spreads to almost every other compartment of his thinking. Since there is still much to learn in this troubled area, one can only welcome the publication of these two studies. O'Daly's book aspires to deal with the entire list of questions involved in the ancient world's Platonic tractatus De anima, whereas Rigby focuses on a single issue, critically evaluating (and largely refuting) the contention put forth by Athanase Sage in two classic articles: that the Augustine who wrote the Confessions had not yet come to think of humanity as guilty of original sin. The breadth of O'Daly's focus also betrays a distinctly confident attitude toward the wide array of matters he must discuss; he seems to view the Augustinian field as relatively trouble free. The central chapters of his book originated as a Habilitation thesis for the University of Heidelberg: hence the generous display of German scholarship, but also a greater serenity toward the difficulties non-German students might perhaps raise against some of his conclusions. He moves from Augustine's general theory of the soul, through claapters on the soul's "lower" activities (sense-perception, imagination, and memory), to that peculiar Augustinian preoccupation with the soul's measurement of time; he then concludes with the psychology of what Augustine would term "knowledge" in the higher (i.e., intellectual) sense of the term. The atmosphere throughout is encyclopedic, but then so is the impressive scale of O'Daly's learning; at the end, though, the reader is especially grateful for the two valuable indices---one topical the other an Index locorum--which help in retrieving the multitude both of texts and topics O'Daly handles. O'Daly is confident that Augustine's views on most of these matters solidified early on, so he feels entitled tojump about from early to late works and back again. Those who 126 JOURNAL OF THE HISTORY OF PHILOSOPHY 28:1 JANUARY 199o find Augustine's thought more fluid will question this methodology, even find it circular ; it supposes a continuity of thought which ought rather to be proven. But this nondevelopmental approach results in another loss--the living sense of context, the controlled excitement that invariably marks Augustine's own thinking, has mostly drained off. This is all the more disappointing since O'Daly writes a pleasing prose style. But that judgment may only reflect the preferential conviction that we still have more exciting things to learn about Augustine's philosophy of human nature than O'Daly is willing to admit. Is this, one wonders, the reason why he ignores the many relevant insights contained in Oliver DuRoy's massive study? He is particularly adamant on the question of the soul's origin, yet one is at liberty to doubt that forty-four years of Augustine's thinking on this gnawing issue can be treated adequately in a... (shrink)

St. Augustine was a consummate artist as well as a great philosopher, and he was deeply concerned with art, beauty and human values. But little attention has been paid to his theory of aesthetics. Now a distinguished Augustine scholar turns to this important subject and offers a book that is at once engaging, comprehensive and complete.

The Clinton Administration stated that the list of values and moral principles generated by the Ethics group reflects "fundamental national beliefs about community, equality, and liberty" and that "these convictions anchor health reform in shared moral traditions." However, these statements are difficult to justify. There is not a moral consensus in America that would justify thorough-going health care reform. In such a context of pluralism, ethicists should seek to move society in the direction of solidarity. The participation of ethicists on (...) the Clinton Task Force was valuable because it showed that health reform is an exercise in social ethics, disseminated the work of ethicists to the entire Task Force, and expanded the experience of the ethicists involved. It may also have accelerated the moral transformation of Americans, which is needed before radical reform can take place. Keywords: American values, Clinton health plan, health care reform CiteULike Connotea Del.icio.us What's this? (shrink)

Assuming that the reader accepts, albeit provisionally, that James's "will" to believe, early and late, implies that his ethics is traversed by a deontological streak, and by a "faith" which implies epistemic form on the relevant facts (both interpretations the writer argued for in two previous essays), a final feature of his position entitles one to interpret his "will" to believe as, not merely a willingness or readiness, but as a controlling resolve, in the strong sense, to interpret the facts (...) in a manner appropriate to our living in the "strenuous mood," a mood which is congruent to our universe viewed as "moral." Consider, as a crucial instance, the will to believe which undergirds the "keeping" of a friendship. (shrink)